ComputerS Role Essays - E-commerce, , Term Papers

Computer'S Role A Computers Role Computer technology not only has solved problems but also has created some, including a certain amount of culture shock as individuals attempt to deal with the new technology. A major role of computer science has been to alleviate such problems, mainly by making computer systems cheaper, faster, more reliable, easier to use. Computers are forever present in the workplace. Word processors-computer software packages that simplify the creational and modification of documents-have largely replaced the typewriter. Electronic mail has made it easy to send messages worldwide via computer communication networks. Office automation has become the term for linking workstations, printers, database system, and other tools by means of a local-area network. An eventual goal of office automation has been termed the paperless office. Although such changes ultimately make office work much more efficient, they have not been without cost in terms of purchasing and frequently upgrading the necessary hardware and software and of training workers to use the new technology. Computer integrated manufacturing is a relatively new technology arising from the application of many computer science sub disciplines to support the manufacturing enterprise. The technology of CIM emphasizes that all aspects of manufacturing should be not only computerized as much as possible but also linked together via a computer communication network into an integrated whole. In short, CIM has the potential to enable manufacturers to build cheaper, higher-quality products and thus improve their competitiveness. Making a telephone cal l no longer should conjure up visions of operators connecting cables by hand or even of electrical signals causing relays to click into place and effect connections during dialing. The telephone system now is just a multilevel computer network with software switches in the network nodes to route calls get through much more quickly and reliably than they did in the past. A disadvantage is the potential for dramatic and widespread failures; for as has happened. The downside of this technology is the potential for security problems. Intruders can see packets traveling on a network and can perhaps interpret them to obtain confidential information. Computer technology has had a significant impact on retail stores. All but the smallest shops have replaced the old-fashioned cash register with a terminal linked to a computer system. The terminal may require that the clerk type in the code for the item; but more and more frequently the checkout counter include a bar-code scanner, a device th at directly reads into the computer the UPC printed on each package. Cash-register receipts can then include brief descriptions of the items purchased, and the purchase information is also relayed back to the computer to cause and immediate adjustment in the inventory data. The inventory system can easily alert the manager when the supply of some item drops below a specified threshold. In the case of retail chains linked by networks, the order for a new supply of an item may be automatically generated and sent electronically to the supply warehouse. In a less extensively automated arrangement, the manager can send in the order electronically by a dial-up link to the suppliers computer. These developments have made shopping much more convenient. The checkout process is faster; checkout lines shorter; and the desired item are more likely to be in stock. Computer technology has been incorporated into automobiles. Computers are involved (CAD systems) not only the design of cars but also in the manufacturing and testing process, perhaps making use of CIM technology. Todays automobiles themselves include numerous computer chips that analyze sensor data and alert the driver to actual and potential malfunctions. Although increased reliability has been achieved by implementing such computerization, a drawback is that only automotive repair shops with a large investment in high-tech interfaces and diagnostic tools for these computerized systems can handle any but the simplest repairs. Science Essays

The Perils of Writing to Someone You Dont Know

The Perils of Writing to Someone You Dont Know The Perils of Writing to Someone You Dont Know The Perils of Writing to Someone You Dont Know By Maeve Maddox From a reader: I have a question.   I work for a large Canadian law firm and Ive noticed that many of the people here do not use Mr. or Ms., but rather address letters to John Smith.  Ã‚  Have I missed something?   Is this proper now? It may not be proper, but sometimes its safer. Addressing a letter in the old days was a fairly straightforward undertaking. If the name of the person was Michael Jones, youd say Dear Sir, or Dear Mr. Jones. If you were writing to a woman you could safely address her, married or unmarried, as Dear Madame. Back when the great goal of most women was to find Mr. Right, you could take a chance on starting a letter Dear Mrs. Jones even if you didnt know the recipients marital status. If she wasnt married, shed probably giggle at the error. In these more enlightened days, knowing how to begin a letter to a person you dont know is like walking through a minefield. Current letter-writing guidelines will tell you to address a man as Mr. Jones and a woman as Ms. Jones, but thats pretty simplistic, given the complications of feminism, reactions to feminism, multiculturalism, and creative child-naming. Ideally, the letter writer will check out the person being written to so as to know what form of address to use. But what if, despite your best efforts, you just dont know? How, for example, would you start a letter to Drew Barrymore, Daryl Hannah, or Michael Learned if you dont know all three are women? How are you supposed to figure out the gender of Jordan Dane, Alex Wright, Cory Black. Elliot Simpson, or Jamie Johnson if you know nothing about them but their names? In the age of the world-wide web, what about a name like Ananda Singh? A name ending in -a looks feminine to me, but in India, Ananda is a guys name. Say that you do know that the person youre writing to is a woman. Are you sure you want to address her as Ms. Jones? She may have a Ph.D. and prefer Dr. Jones. She may be a reactionary housewife and detest being called Ms. Or maybe shes single and proud of it and wants everyone to address her as Miss Jones. The people at your law firm are probably less concerned about proper usage than they are about avoiding ruffled feathers. Sometimes the best course of action is to play it safe by using the full name instead trying to juggle a courtesy title. Want to improve your English in five minutes a day? Get a subscription and start receiving our writing tips and exercises daily! Keep learning! Browse the Business Writing category, check our popular posts, or choose a related post below:70 Idioms with Heart50 Idioms About Roads and PathsComma After Introductory Phrases

The Consequences for Women of the 1867 Reform Act Essay

The Consequences for Women of the 1867 Reform Act - Essay Example According to Paula Bartley, this could be compared to the slave trade, â€Å"Is one half of the human species, like the poor African slaves, to be subject to prejudices that brutalise them...only to sweeten the cup of men† (Bartley, 2007). The consequences for the suffrage movements The Great Reform Act of 1832 in the United Kingdom was started by Jeremy Bentham and William Thompson. During this time, United Kingdom had become so corrupt because the constituencies were represented by rich land owners. Elections were unfair because there were many cases of bribery and corruption. Also, by the year 1812, many women practiced prostitution highly in the United Kingdom. Prostitution was fueled by the social, literacy and cultural behaviors of the people living in England. This is the time when many associations were formed with an objective of bringing change and social purity (Bartley, 2007). A centre for home of friendless girls was introduced to educate the young girls on the ne ed for obedience and self control. This was due to the unhygienic nature of the practice since it led to contagious diseases. The reformers explained the causes of prostitution and came up with a strategy to educate the youth on positive change. Industrial capitalism also changed and minimized prostitution. â€Å"Surely, it will not be denied that woman have, and ought to have opinions of their own on subjects of public interest, and on the events which arise as the world goes its way† (Bartley, 2007).This led to the second reform act in 1867. . In 1819, Charles Woolsey won the elections and went to the House of Commons to initiate change as the legislative representative. Also, the committee of Manchester which consisted of twenty thousand to sixty thousand people appointed a representative attorney. In 1820s, parliament neglected new reforms. This was when John Russell disagreed with the corrupt activities of the parliamentary members. The Great Reform Act was proposed by J ohn Russell in the year 1830 after the death of King George. It was after the dissolution of the parliament, and the general elections were to be held. Birmingham political union started its campaigns under the leadership of Thomas Attwood. The campaigners put emphasis on the issue of reforms as this bill was pending in the previous parliamentary sittings. After the elections three reform bills passed to the parliament and through subsequent debates the bills were then amended to be the Great reform act in the year 1832. After this act, political education began whereby politics and social education were introduced to the local citizens. After the great reform, there was insufficient voter registration exercise and most people did not have the votes. Bribery and corruption remained to be a significant problem in the governance. During the ensuing years, corruption wars started up to the year 1854 when the corruption practices act passed into law by the parliament. Civil wars began w hich aimed at changing the structure of governance in England. There were outstanding family problems in the society. Divorce cases had increased. This act separated sex from reproduction. Same sex had become so prominent in the society. Sexual and social reforms in the society were the campaign strategies by the reform parties. In certain areas like New Jersey, the law allowed only

Read instructions Essay Example | Topics and Well Written Essays - 750 words - 1

Read instructions - Essay Example Through caste system, everybody who is born in the society knows what is expected of him or her and this in turn ensures distribution of human capital in all important professions. There are 4 major castes, namely Brahmans, Kshatriyaas, Vaishayas, and Shudras. These castes included religious scholars, rulers and soldiers, farmers and traders, and common unskilled workers respectively (Jaffrelot, 174). The purpose of each caste was fixed and, therefore, a proper balance of all professionals existed in the society. This is one of the major advantages of caste system. Caste system also ends power struggle and violence in the society as everyone is aware of his or her job. No farmer or trader will have an ambition to become a soldier or ruler, and no similarly religious scholar will want to become rule. This puts an end to power struggle in the society and decreases violence related to power to a certain extent. Disregarding the demerits of caste system on individuals, one of its main advantages of caste system is that it creates a society where there is political stability. This can be termed, in a way, as an advantage of the caste system. The caste system has many disadvantages for common man. There is no chance for social mobility in a society with caste system and this can create significant disparity between rich and poor. A poor and socially downgraded person will never have a chance to improve the situation of his or her family. There is monotony in the lives of people who live under a caste system and this monotony is not easy to get rid of. A person has to live all his life with the label with which he was born. There is no chance to break away from the identity one is given at the time of birth. Another disadvantage of caste system is that it destroys principles of merit and skill. The intellectual ability of a person is determined from the caste in which he or she is born, and not by characteristics of his

Ethics Assignment Example | Topics and Well Written Essays - 500 words - 5

Ethics - Assignment Example gher standard of behavior by society, because they are stewards of the public trust and are empowered to apply force and remove constitutional privileges when lawfully justified† (Gleason). Police does not only take an oath of protecting the nation, but is also expected to adhere to the highest standards of ethics and respect the laws they enforce upon others. Proper ethical training helps the police recognize ethical dilemma, identify solutions, select the most appropriate solution from among a range of options, take prompt action, and take responsibility for the consequences. There are certain strategies that the police leaders can adopt to instill ethics in the organization. (Zuidema and Duff) highlight some of them; The police leaders should make the ethical behavior a necessary part of the organization’s mission and values. These values include but are not limited to leadership, dedication, and professionalism. This way, it becomes more convenient for the employees of the police department to recall the terms since they are part of in the organization’s initials. The best way to achieve this effect is to display the values of ethical behavior for the officers and the community members on the brochures, website, and cars used by the organizational personnel. The police leaders should emphasize upon the ethical behavior in such organizational events as meetings and sessions of training and skill development. Inviting the sworn officers of law enforcement at all public ceremonies held by the organization to recite the oath of honor can be a potential way to achieve this. Police departments can also place emphasis on the ethical behavior in the philosophy of their organization. For example, the officers may be granted the power to solve problems individually and make the required decisions in mutual consensus with the citizens. If the officers are granted this right, this would not only make them more particular about the ethical concerns and implications

Cellular Metabolism and the Immune Response Control

Cellular Metabolism and the Immune Response Control PRESTES, A. F. R. O.1; KONDO, F. V.2; HUETE, G. C.3; MURILLO, O.4 Keywords: mTOR, metabolism, Akt, immune system, regulation, mitochondria, inflammatory and anti-inflammatory I. Introduction Metabolism and immune system: The metabolic system was seen only as a system of power generation and metabolites for the functioning of cells. Today we know that changes in metabolic regulation may interfere directly in diseases that involve inflammatory processes. Thus, knowledge of the relationship between metabolism and cell signaling helps in understanding metabolic disorders, cancer, and also in the study of immune response (1,2). The relationship between metabolic and regulatory aspects of the immune system is not yet fully known. Even with major discoveries on the subject, the metabolism of many cells of the immune system is unknown (1,2). The metabolic changes during phagocytosis of three types of immune cells from pigs, leukocytes and peritoneal exudate monocytes and alveolar macrophages. In this study it was observed that macrophages depend on oxidative phosphorylation to produce energy during phagocytosis, whereas the other two cells only use glycolysis to produce energy (3). Another study confirms the close relationship between immune system and metabolism, which showed that incubation of dendritic cells (differentiated in vitro) with LPS provides an increase in glucose consumption, increased formation of lactate and reduction in oxygen consumption. Furthermore, these changes also reflected in increased CD86 co-stimulatory molecule indicating a functional modulation of these cells (4). The need for meta bolic resources to build active components of the immune system, the messenger function of certain classes of metabolites and metabolites, and the intimate relationship between parasite and mammalian defense mechanism, which is probably immune regulatory events are reflected in the metabolism (5). The metabolic profile of the cells of the immune system is also important to provide a tool that generates a systemic metabolic description induced by the parasite in the host, promoting a new direction of the immune response during infection by the parasite (5). In most biological systems, there is a stimulus that triggers an effector response, which usually makes the system back to the starting point. Although having different primary functions, the immune system and metabolic pathways are arranged in the same manner as in serum glucose levels in thermogenesis or bacterial infection, where the lipopolysaccharide stimulates TLR-4 receptor, which promotes the release of TNF-ÃŽ ±, improving bactericidal activity and vascular permeability reducing infection (2). Metabolism and associated pathways Akt/PI3K/mTOR: As well as the metabolic pathways generate energy, the means of regulation of protein synthesis involves several intracellular signaling pathways such as Akt as Akt (serine/threonine kinase), expressed in heart, lung, brain and skeletal muscle. Various stimuli, such as cytokines, growth factors and hormones, are responsible for the phosphorylation and activation of Akt, which is composed of three members, Akt1, Akt2 and Akt3 (6). The Akts proteins are recruited to the plasma membrane by PI3K, which acts as a lipid kinase. The Akt/PI3K pathway operates in promoting cell survival through evasion of apoptosis and cell proliferation through activation of mTOR in response to nutrient availability and to stimulation by growth factors. The mTOR protein stimulates translation that is required for cell cycle progression (7). mTORC1 activation is indirectly given when Akt phosphorylates TSC-2 one of the molecules of heterodimer TSC1 and TSC2, this activates the GTPase function of this heterodimer which reverses the inhibition of mTORC1, inhibiting RHEB to pass the ADP to ATP linked to this protein, by activation of cyclase function of the TSC heterodimer (8). Akt phosphorylation is important for neutralization and PRAS40, important for the activation and interactions mTOR1 and mTOR2 with their substrates (9). Thus, the mTOR pathway is also known as PI3K/Akt/mTOR. Despite the multiple substrates involved in this pathway. Additionally, Akt is not limited to this path and fulfills other functions at the cellular level. Metabolism and mTOR: Mammalian Target of Rapamycin is a serine/threonine protein kinase involved in regulation of many cellular events, such growth, survival, function, metabolism, and differentiation. It is constitutively expressed, and its regulation occurs predominantly post-translationally (7). This protein was discovery from searches about target of Rapamycin, that was originally found as a growth inhibitor which have immunosuppressive and anticancer properties (10). Additionally, due to the ability of mTOR activation to regulate metabolism, it promotes a crucial link connecting metabolic demands and cellular function (7). This link is mediated through the control of key transcriptional regulators. (11). mTOR fathers two functionally distinct signaling multi-protein complexes: mTORC1, which is composed of the scaffolding regulatory-associated protein of mTOR (RAPTOR), DEP domain containing mTOR-interacting protein (DEPTOR), Proline-Rich Akt Substrate 40 kDa (PRAS40), and mammalian Lethal with Sec13 protein 8 (mLST8); and mTORC2, which is composed of RAPTOR-independent companion of TOR (RICTOR), protein observed with RICTOR (PROTOR), mSIN1 proteins, mLST8 and DEPTOR. The connection of mTOR with these adapter proteins has functional distinct consequences (3,4). II. Metabolism and T cells differentiation Such described previously, the mTOR ability to play a role in cellular differentiation occurs through the regulation of transcription regulators. Follow, some these regulators and its role in metabolic programs regulation. HIF-1: The Hipoxia-inducible Factor is a hetrodimeric protein which regulates the expression of various genes crucial for cellular adaptation to a low-oxygen environment. This protein supports the differentiation of naà ¯ve CD4+ T cell to Th17 cell through the stabilization of the RORÃŽ ³t expression, as well as inhibits Treg differentiation through the inhibition of Foxp3, mediating its proteosomal degradation (3,5). Myc: The oncogenic transcription factor Myc regulates various metabolic pathways essentials for cellular growth and proliferation, such glycolysis, glutaminolysis, and fatty acid oxidation (14). PPARÃŽ ±: The peroxisome proliferator-activated receptor ÃŽ ± (PPARÃŽ ±) is a nuclear hormone receptor that regulates fatty acid metabolism and glucose homeostasis, playing a role as a intracellular sensor of endogenous fatty acids. This receptor induces Treg differentiation and inhibits effector differentiation (11). PPARÃŽ ³: Like its homolog PPARÃŽ ±, PPARÃŽ ³ is a nuclear hormone receptor that regulates adipogenesis, lipid metabolism and glucose homeostasis in cells. This receptor plays the same role in T cell differentiation (11). SREBP: The sterol regulatory element binding proteins (SREBP) plays a critical role in regulating cellular lipogenesis, facilitating the anabolic enzymes transcription, which is involved in cholesterol and fatty acid synthesis (11). This protein was found to associate with the IL17 promoter, where it interacts with and inhibits the activity of the aryl hydrocarbon receptor. This transcription factor is known to be important for expression of Th17-associated genes (5,7). Once the antigen is recognized, the integration of many factors from the microenvironment gives the effector fate of the naive CD4+ T cell. Until now, the T-cell subsets have been characterized only by their transcription factor expression and cytokine secretion profile. Nevertheless, it has currently proposed that each T-cell subset also hold a single metabolic profile and a corresponding set of signal requirements of mTOR complexes (11). According this metabolic classification, the T-cell would present these features: Th1 T cells phenotype exhibit a strong glycolytic phenotype and express high levels in surface of the Glut1 glucose transporter. Its development is dependent on the mTORC1 signaling complex (3,8). Th2 T cells phenotype also express high levels in surface of the Glut1 glucose transporter and exhibits a high rate of lactate production and glucose uptake following stimulation. These cells can develop in absence of mTORC1 but are dependent on the mTORC2 signaling complex (3,8). Th17 cells phenotype is the higher glycolytic T-cell subset. The IL-17-secreting CD4+ T cells development drastically decreases in T cells lacking mTOR, mTORC1 and treated with Rapamycin. Nevertheless, T cells lacking mTORC2 does not appear to have its development inhibited (3,8). Treg cells phenotype exhibits an oxidative metabolic profile which uses mitochondrial respiration and fatty acid oxidation to achieve energy. The treatment with process of glycolysis inhibitor compounds in naive CD4+ T cells importantly enhance its development, what also occurs with culture conditions that conduces to a low mTOR signaling (3,8). III. Regulation of cell B by mTORC The PI3K pathway to mTOR is required for B cell proliferation. Since the BCR is blocked by inhibition of mTOR. This was evidenced in mouse spleen cells, wherein inhibition of mTOR suppresses the proliferation and differentiation of B cells by CD40 (10,11). In humans, Rapamycin suppresses B cell proliferation when is activated in the presence of CD40L and B cell inducing cytokines. Rapamycin prevents antibody-mediated apoptosis, generating a reduction of B cells that produce IgG and IgM, also suppresses the production of cytokines that induce proliferation of B cells and IgM, as IL-2 in inflammation conditions (18). Some authors suggest that mTOR regulates IL-17, which is important in the proliferation of pro-B cells. Thus, if rapamycin in B-precursor acute lymphoblastic leukemia cell lines is evidence that IL-17 induces apoptosis in these cells is used. But when S1N1, an important element of mTORC2, is suppressed cell survival is increased possibly by the increased expression of IL-7R (20). In mature B cells, activation of TLRs and BCR induces activation of mTOR, even so, have been identified as Akt independently of mTOR regulates the BCR and this is accomplished by inactivating FoxO1 which is sequestered and degraded in cytoplasm after Akt is phosphorylated (21). When is deleted TSC1 or TSC2, is inhibited the maturation of cells B, contrary to what happened when Akt was active, in where B cells were significantly reduced in the marginal zone (MZ). But when rapamycin was fed this phenomenon was corrected, and once again the importance of mTOR is displayed in the control populations of B cells in MZ. Despite all the evidence to date is known that the PI3K pathway is a major regulatory functions and populations of B cells through regulating FoxO1. But do not have enough information to indicate the direct role of mTOR in the control and regulation of B cells, which is still under study and demonstration (22). IV. Metabolism and APCs Regulation Dendritic Cells (DC): crucial regulators of both cellular activation and tolerance in adaptive immune responses. The function which DC will perform depends on their activation and differentiation status (23). The DC activation occurs through PAMP stimulation of TLR, what leads a metabolic transition in the resting immature DC, which is characterized by a conversion from mitochondrial b-oxidation of lipid and OXPHOS to aerobic glycolysis (9,10). Once exposed to TLR agonists, in an early phase, the lacking of glucose in culture medium leads to critical faults in DC activation, such production of IL-12p40 and surface expression of CD40 and CD86. Afterwards, DCs activated by TLR signals are highly dependent on glucose for survival, becoming more sensitive to apoptosis by nutrient limitation. Thus, for full DC activation is essential initiating glycolysis at the time (9,10). Differently than OXPHOS, glycolytic pathway may be requested due to the necessity to produce substrates which will be used during DC activation. As an option, glycolytic pathway components can control protein translation and can be responsible to regulate the translation of crucial proteins for DC activation (24). Macrophagues: Macrophages can be classified into two major groups M1 (inflammatory) and M2 (anti-inflammatory). And each type of macrophage used different metabolic pathways, M1 uses energy mainly anaerobic glycolysis, mediated by HIF-1ÃŽ ±, while M2 employs FAO mediated PPARÉ ¤ and PGC-1ÃŽ ² (26). Evidencing with this, the relationship with of the metabolic function and and the population of macrophages. This regulation may be mediated by mTOR, which is an important nutrient sensor / power as processes such as protein synthesis, autophagy, glycolysis and regulation of immune response, de novo lipogenesis, among others. (27) Natural killer cells (NK cells): The NK cells rapamycin inhibits proliferation by blockade of the cell cycle in G1 phase in rat. Nevertheless, rapamycin does not affect interferon production by NK cells. When mTOR is inhibited in vitro, the death of T-cell YEC-1mediated by NK cells decreases slightly. In vivo, rapamycin reduces the number of NK cells in rat liver allografts (10). Neutrophils: Human neutrophil is inhibited the chemotaxis and chemokinesis induced by GM-CSF, when rapamycin is delivered. The same way, the response to IL-8. Rapamycin reduces polymerization of actin, important for leukocyte migration. mTORC1 is linked in activation of neutrophils and acute lung injury in association with TLR2 and TLR4 (18). V. Mitochondrial metabolism and regulation of immune response Effect Warburg: Is a termination used to describe a mechanism of some cancer cells to metabolize glucose via glycolysis, where the conversion of glucose to lactate with oxygen available to obtain energy with rapid generation but less efficient pathway for obtaining ATP (20,21). Carbon precursors necessary for the synthesis of nucleic acids, phospholipids, fatty acids, cholesterol and porphyrins can be provides by glycolysis (28). Glycolysis in normal tissues is the metabolism of 6-carbon glucose to 3-carbon pyruvate and the energy in the form of ATP occur via oxidative phosphorylation in mitochondria (30). Hexocinase-2 (HK-2) is an isoform over-expressed in many cancer cells and is located on the external mitochondrial membrane protein VDAC (voltage-dependent anion channel). HK-2 has preferential access to mitochondrial generated ATP via the mitochondrial adenine nucleotide translocator (ANT), and protection from inhibition by its product G-6-P. Cancer cells have overproduced HK-2 and making the reaction between ATP and the incoming glucose to produce G-6-P at a high rate (30). Studies suggest a link between cancer cells and Hif-1a, where high Hif-1a activity is demonstrated to mediate the Warburg effect. HIF-1a is able to produce enzymes hexokinase 2, triosephosphate isomerase, isomerase, glucose 6-phosphate, and pyruvate kinase M2 (PKM2) in glycolysis (31). HIF-1 is a transcription factor responsible for the change of gene expression during cellular response to low oxygen conditions. Amplifies HIF-1 transcription of genes encoding glucose transporters and glycolytic enzymes (32). Recent studies show Warburg effect have many mechanisms: tumor microenvironment and stabilization of HIF, oncogene activation and loss of tumor suppressor genes, mitochondrial dysfunction in cancer cells, nuclear DNA mutations, epigenetic changes, miRNA, glutamine metabolism, and post-translational modifications (28). Metabolic pathways and importance in the differentiation and function of immune cells: The response, proliferation, polarization or action of immune cells requires the supply of nutrients and high energy consumption, for this reason the contribution of ATP for these functions comes from differential form of the various metabolic pathways, from glycolysis, to pyruvate until lactate production or acyl-CoA, to enter the tricarboxylic cycle acid (TCA); or through of the fatty acids oxidation (FAO). Producing enough electrons (NADH and FADH2) to activate of the electron transport chain to fuel oxidative phosphorylation (OXPHOS) (1). It is also already considered that myeloid cells such as granulocytes, dendritic cells, macrophages, B cells and T cells mainly use glycolysis as a source of ATP via anaerobic when they present an effector or inflammatory profile (Figure XX)(1,2). This is evidenced by neutrophils that have few mitochondria and consume little oxygen (34). Under these conditions the Warburg effect is generated. Producing lactate and NADPH, an essential cofactor for the NADPH oxidase for the production of important microbicidal product H2O2 (35). Some authors suggest that eosinophils and basophils are metabolically similar to neutrophils (36) As with neutrophils, macrophages are important in the immune response and are distributed in all organs and tissues. Playing an important role in innate immunity and adopt different states of activation. Interferon-É ¤ (IFN-É ¤), in combination with TLR agonists, induces M1 (inflammatory), while IL-4 and IL-13 cytokines induces M2 (regulators) (37). M1 macrophages secrete IL-12, IFN-gamma promotes, thus inducing NK cells and T cells, addition of TNF-ÃŽ ±, that activate other immune cells, and NO. Contrary M2 macrophages, secret anti-inflammatory molecules and stimulate tissue repair. Activation of M1 and M2 is characterized by the use of different metabolic pathways (38). M1 using arginine as a substrate to produce iNOS occurs only in the M1, and not in M2. M2 using arginine as a substrate for Arginase1 expressed only in the M2, and not in M1(37). The M1 macrophages possess a glycolytic metabolism. Similar to the different types of activated cells such as dendritic cells and granulocytes. (Figure XX). The Macrophage M1 has higher basal mitochondrial oxygen consumption, the other macrophages. M2 macrophages inducing the mitochondrial OXPHOS through of IL-4 and FAO. in such a way, metabolism M2 is strongly biased towards the use of FAO and mitochondrial respiration to meet their energy needs (Figure XX) (39). DCs derived from cultured bone marrow stimulated with colony-stimulating factor granulocyte-macrophage, are a model of production of TNF-ÃŽ ± and inducible nitric oxide synthase (iNOS). At rest, the DCs oxidize glucose in the mitochondria, by OXPHOS, with little lactate production. But, once stimulated with TLR agonists, become dependent on Warburg metabolism to subsistence (40). PI3K and Akt are important in the activation of glycolytic metabolism (41); play an important role in the duration of glycolysis in DCs activated. As evidenced by DCs activated by more than 12 hours which increases glucose consumption and TCA and mitochondrial oxygen consumption cease (40), increasing lactate production, and the cells survive only by aerobic glycolysis (Fig. XX). The high production NO gas by iNOS from arginine, inactive mitochondrial respiration in these cells. So the activation of glycolytic metabolism in activated DCs induces the expression of iNOS and production of NO thus inhibits OXPHO S. This subsistence mechanism is vital for the rapid production of ATP in the absence of machinery for the production of mitochondrial ATP (42). As the cells of the innate immune system, the T and B cells activated Warburg metabolism used at the time of the proliferation. In contrast to most of innate cells, which use Warburg metabolism after activation but not proliferate (1). Contrary to activated effector T cells, memory T and B cells do not use aerobic glycolysis but if they use mitochondrial FAO for their development and persistence, maintain or adopt a catabolic metabolism (Figure XX) (43). Once an antigen recognized by naive T cells and with adequate costimulation, this growth rapid, proliferation, and acquisition of specialized effector functions is initiated. This requires of the T cell a metabolic reprogramming and energetic. This pass of a catabolic metabolism to an anabolic metabolism, changes the cell is not in a state of maintenance and homeostasis (1). Some molecules such P13K, Akt, Myc, and HIF are associated with immune and metabolic signals for the activation, function, development and upkeep of T cells. So the metabolic pathways induce a T helper subsets (1). As was evidenced in Treg cells mainly use mitochondrial OXPHOS and FAO for their development and subsistence (17) or in Th17 cells where glycolysis is primarily required (44). In activated T cells the IL-12 induce an increase in the glucose transporter and glycolytic metabolism. Besides glycolysis in maintaining the activity of active effector T cells, exist other pathways involved, as via the pentose phosphate and glutaminolysis as well as the use of key molecules such as citrate and malate (Figure XX) (1).It is important to consider the available nutrients, substrates, or other resources that can create an imbalance in the environment of immune cells, affecting the metabolism of cell function and fate of immune cells. Mitochondria in the production of iNOS and inflammation: All metabolic process to generate ATP by OXPHOS generates ROS, which are involved in oxidative stress of the mitochondria. Production of O2- in excess, induces activation of factors of redox-sensitive transcription, such as NF-kB, and thus an increase of cytokines, chemokines, inducible nitric oxide synthase (iNOS), eicosanoids, and adhesion molecules (45). Some of these superoxide anions combine with nitric oxide (NO) to produce peroxynitrite (ONOO-), a powerful oxidant. These ROS oxidize proteins, membrane lipid and mtDNA; damaging mitochondrial integrity (46). Being mitochondria, the inducer of the pro-inflammatory action by the action of innate immunity using redox sensitive or direct inflammasome activation molecules. Progression that result in the immediate activation of caspase-1, and subsequent activation of the inactive precursor of IL-1ÃŽ ² and IL-18 (47). DAMPs activate the same receptors that detect PAMPs, such as TLRs and cytoplasmic NOD and NLRs (46). Once activated, NLRP3 this is depolymerized and induces the recruitment of the adapter protein ASC and caspase-1 (and her cleavage), and other cytoskeletal proteins, glycolytic enzymes and caspase-7. This group of proteins called inflammasome. This complex induces pro-inflammatory, such as IL-1ÃŽ ² and IL-18.(47). Elevated levels of ROS generated by the mitochondria activate NLRP3 inflammasome. Interestingly, the humidity and the myth-AMPS can activate APCs, as well as other non-immune cells including mesenchymal stem cells and astrocytes. Additionally, IL-1ÃŽ ² pro-inflammatory IL-6, MCP-1 and TNF is induced by degradation of mtDNA in mouse primary astrocytes. (48). This activation of the inflammasome can activate NF-kB, increasing even more pro-inflammatory cytokines duration of the inflammatory response. This summation of events can be a clear explanation to the high deterioration of mitochondria (46). Biogenesis of mitochondria: The availability of nutrients and oxygen can determine the function of a time cell proliferate and differentiate. Under normal conditions the cell has high level out of ATP/ADP/AMP. Thus, an increase in AMP activates AMPK, activating ATP production by activating TSC 1 and 2 which blocks mTOR (7). After ATP levels are increased activated Akt/PKB promotes mitochondrial biogenesis by phosphorylation and nuclear translocation of NRF-1 and nuclear translocation with increased mitochondrial hexokinase (HK), using glycolysis coupled to OXPHOS with uptake mitochondrial ATP, especially in order to allow cell survival and maintenance of cell functions (49). An important protein in the biogenesis of mitochondria is BAD, which is involved in the initiation of a protein complex that catalyzes the first step of glycolysis by deHK-4 activation. But absent BAD gives a restriction of respiration in the presence of glucose and in the absence of glucose dephosphorylated BAD and induces apoptosis(50). This interaction between energy metabolism and the regulation of apoptosis, is important in mitochondrial biogenesis, and any imbalance can lead to mitochondrial failure and loss problems inducing pathological cell survival (51). Thus, the whole process of inflammation, oxidation and apoptosis, requires a high rate of mitochondrial replacement to allow the restoration of damaged mitochondria continuously and cell survival, which may serve as a signal that stimulates the production of mediators anti-inflammatories such as the IL-10. This is evidenced by the increased immune tolerance during periods of mitochondrial biogenesis may be a risk for recurrent or secondary infections evidencing with them a close relationship between immunosuppression and the regeneration of the mitochondria, this period of immunosuppression may be greater depending the damage level of the mitochondria involved in the initial inflammatory process.(49). VI. References 1. Pearce EL, Pearce EJ. Metabolic pathways in immune cell activation and quiescence. Immunity. Elsevier Inc.; 2013 Apr 18;38(4):633–43. 2. Odegaard JI, Chawla A. The immune system as a sensor of the metabolic state. Immunity. Elsevier Inc.; 2013 Apr 18;38(4):644–54. 3. Oren R, Farnham AE, Saito K, Milofsky E, Karnovsky ML. Metabolic patterns in three types of phagocytizing cells. J Cell Biol. 1963 Jun;17:487–501. 4. Krawczyk CM, Holowka T, Sun J, Blagih J, Amiel E, DeBerardinis RJ, et al. Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation. Blood. 2010 Jun 10;115(23):4742–9. 5. Saric J. Interactions between immunity and metabolism contributions from the metabolic profiling of parasite-rodent models. Parasitology. 2010 Aug;137(9):1451–66. 6. Datta SR, Brunet A, Greenberg ME. Cellular survival: a play in three Akts. Genes Dev. 1999 Nov 15;13(22):2905–27. 7. Powell JD, Pollizzi KN, Heikamp EB, Horton MR. Regulation of immune responses by mTOR. Annu Rev Immunol. 2012 Jan;30:39–68. 8. Castro AF, Rebhun JF, Clark GJ, Quilliam LA. Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner. J Biol Chem. 2003 Aug 29;278(35):32493–6. 9. Wang L, Harris TE, Roth RA, Lawrence JC. PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding. J Biol Chem. 2007 Jul 6;282(27):20036–44. 10. Sabatini DM. mTOR and cancer: insights into a complex relationship. Nat Rev Cancer. 2006 Sep;6(9):729–34. 11. Waickman AT, Powell JD. mTOR, metabolism, and the regulation of T-cell differentiation and function. Immunol Rev. 2012 Sep;249(1):43–58. 12. Laplante M, Sabatini DM. mTOR signaling at a glance. J Cell Sci. 2009 Oct 15;122(Pt 20):3589–94. 13. Barbi J, Pardoll D, Pan F. Metabolic control of the Treg/Th17 axis. Immunol Rev. 2013 Mar;252(1):52–77. 14. Wang R, Dillon CP, Shi LZ, Milasta S, Carter R, Finkelstein D, et al. The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity. 2011 Dec 23;35(6):871–82. 15. Barbi J, Pardoll D, Pan F. Metabolic control of the Treg/Th17 axis. Immunol Rev. 2013 Mar;252(1):52–77. 16. Cui G, Qin X, Wu L, Zhang Y, Sheng X, Yu Q, et al. Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation. J Clin Invest. 2011 Feb;121(2):658–70. 17. Michalek RD, Gerriets VA, Jacobs SR, Macintyre AN, MacIver NJ, Mason EF, et al. Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. J Immunol. 2011 Mar 15;186(6):3299–303. 18. Thomson AW, Turnquist HR, Raimondi G. Immunoregulatory functions of mTOR inhibition. Nat Rev Immunol. 2009 May;9(5):324–37. 19. Sakata A, Kuwahara K, Ohmura T, Inui S, Sakaguchi N. Involvement of a rapamycin-sensitive pathway in CD40-mediated activation of murine B cells in vitro. Immunol Lett. 1999 Jun 1;68(2-3):301–9. 20. Lazorchak AS, Liu D, Facchinetti V, Di Lorenzo A, Sessa WC, Schatz DG, et al. Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells. Mol Cell. 2010 Aug 13;39(3):433–43. 21. Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell. 1999 Mar 19;96(6):857–68. 22. Benhamron S, Tirosh B. Direct activation of mTOR in B lymphocytes confers impairment in B-cell maturation andloss of marginal zone B cells. Eur J Immunol. 2011 Aug;41(8):2390–6. 23. Dong H, Bullock TNJ. Metabolic Influences That Regulate Dendritic Cell Function in Tumors. Front Immunol. 2014 Jan;5:24. 24. Dong H, Bullock TNJ. Metabolic Influences That Regulate Dendritic Cell Function in Tumors. Front Immunol. 2014 Jan;5:24. 25. Krawczyk CM, Holowka T, Sun J, Blagih J, Amiel E, DeBerardinis RJ, et al. Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation. Blood. 2010 Jun;115(23):4742–9. 26. Vats D, Mukundan L, Odegaard JI, Zhang L, Smith KL, Morel CR, et al. Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation. Cell Metab. 2006 Jul;4(1):13–24. 27. Byles V, Covarrubias AJ, Ben-Sahra I, Lamming DW, Sabatini DM, Manning BD, et al. The TSC-mTOR pathway regulates macrophage polarization. Nat Commun. Nature Publishing Group; 2013 Jan;4:2834. 28. Upadhyay M, Samal J, Kandpal M, Singh OV, Vivekanandan P. The Warburg effect: insights from the past decade. Pharmacol Ther. Elsevier Inc.; 2013 Mar;137(3):318–30. 29. Xie J, Wu H, Dai C, Pan Q, Ding Z, Hu D, et al. Beyond Warburg effect dual metabolic nature of cancer cells. Sci Rep. Nature Publishing Group; 2014 Jan;4:4927. 30. Mathupala SP, Ko YH, Pedersen PL. Hexokinase-2 bound to mitochondria: cancer’s stygian link to the â€Å"Warburg Effect† and a pivotal target for effective therapy. Semin Cancer Biol. 2009 Feb;19(1):17–24. 31. Palsson-McDermott EM, O’Neill L a J. The Warburg effect then and now: from cancer to inflammatory diseases. Bioessays. 2013 Nov;35(11):965–73. 32. Cairns R a, Harris IS, Mak TW. Regulation of cancer cell metabolism. Nat Rev Cancer. Nature Publishing Group; 2011 Feb;11(2):85–95. 33. Kominsky DJ, Campbell EL, Colgan SP. Metabolic shifts in immunity and inflammation. J Immunol. 2010 Apr 15;184(8):4062–8. 34. Van Raam BJ, Verhoeven AJ, Kuijpers TW. Mitochondria in neutrophil apoptosis. Int J Hematol. 2006 Oct;84(3):199–204. 35. Dale DC, Boxer L, Liles WC. The phagocytes: neutrophils and monocytes. Blood. 2008 Aug 15;112(4):935–45. 36. Sumbayev V V, Nicholas SA, Streatfield CL, Gibbs BF. Involvement of hypoxia-inducible factor-1 HiF(1alpha) in IgE-mediated primary human basophil responses. Eur J Immunol. 2009 Dec;39(12):3511–9. 37. Murray PJ, Wynn TA. Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol. 2011 Nov;11(11):723–37. 38. Rodrà ­guez-Prados J-C, Travà ©s PG, Cuenca J, Rico D, Aragonà ©s J, Martà ­n-Sanz P, et al. Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activat

Legal Provisions Concerned with Business Units :: Business Management Companies Essays

Legal Provisions Concerned with Business Units Our client is in the process of forming a company. She wishes to avoid personal liability upon any contracts she may enter into on behalf of the proposed company. Our job is to design a report to explain the legal provisions concerned with the formation, management and dissolution of business units. The report will identify the relevant legal principles, which can influence the choice of business unit. Explain the differences in the regulatory approach adopted for partnerships and registered companies and describe the procedures for the dissolution of business units. At the end of the report we will advise our client what type of company would be best suited to her needs. There will also be a presentation to go with the report highlighting the main points. 2.TYPES OF COMPANY There are many different types of business unit. Each is formed by a group of people with a common aim. Britain has what is known as a mixed economy where goods and services are supplied by both private and public sector organisations, as shown in the following diagram: Private Enterprise Sole Trader Partnerships Limited Companies Co-operatives Private Public Retail Producer Public Enterprise Public corporations Government Departments Local Authorities The private sector/enterprise is the term used to describe all businesses which are owned by individuals or groups of individuals and run essentially for profit. About half of all trading in Britain is controlled by private sector organisations. The other half known as the public sector/enterprise are businesses which are owned and controlled by the government or Local Authorities and run for the benefit of the country. The sector this report is concerned with is the Private Sector. 2.1 SOLE TRADER This is the oldest, simplest and therefore most common form of business unit. A sole trader is one who conducts their business by themselves either using their own name or a business name. This is somebody who is self-employed and who usually starts a business with capital from their savings or by borrowing from friends or a bank. Capital is the money which every business needs to enable it to set up and operate, for example to buy premises, equipment, stock and pay wages. The main advantage is that you can be flexible. You don’t need to discuss with others (e.g. partners and directors) how you are going to run the business. You also have less paperwork. A sole trader is not necessarily a one-person business and may have many employees or branches. However, the business is owned by one person and it is they who receive the profits. ADVANTAGES DISADVANTAGES - Business affairs can be kept private except for completing tax

Human Nature vs Personal Gain Essay

Growing, learning and becoming the best we can be are all positive steps that evolve from life experience. It is human nature that wants to succeed and contribute to society in productive ways. In the play The Crucible, written by Arthur Miller, individuals display an ugly side of human nature and are motivated by less than noble goals. Throughout the story, justice is often replaced by the desire for personal gain. Perhaps the three best reasons are greed, selfishness and betrayal. Greed is a motivating factor among many individuals in the play. At many times, John Proctor talks with Hale about Parris’s need to become rich, by gathering valuable golden candlesticks. He says, â€Å"He preach nothin’ but golden candlesticks, until he had them†¦ I think, sometimes, the man dreams cathedrals, not clapboard meetin’ houses† (Miller 65). Proctor says this to Parries to illustrate Parris’s materialistic nature and thirst for power, land and material p ossessions. Like Reverend Parris, Thomas Putnam is also greedy. Thomas uses his daughter to falsely accuse George Jacob of witchcraft. The accusation leads to the arrest and conviction of George Jacob by Judge Danforth. Giles Corey’s explains to Danforth that Mr. Putnam is dishonest and says â€Å"If Jacobs hangs for a witch he forfeit up his property- that’s law! †¦ This man is killing his neighbors for their land† (Miller 96). Thomas Putnam uses these falsifying witchcraft trails to increase his own wealth by accusing people of dealing in witchcraft, getting them convicted and then taking advantage of the situation by buying up their property. Characters like Parris and Putnam are so obsessed with greed that they do not have a conscience. Just as the evils of greed occupy Parris and Putnam, Abigail Williams is motivated by selfishness. She is vengeful, manipulative and a magnificent liar; for example, she goes into the forest at night and practises witchcraft with the other girls form the village. However, when Abigail is confronted about her disgusting behaviour, she chooses to keep  h er well respected reputation intact. Abigail denies that she was in the forest dancing that night, threatens the girls and says, â€Å"Now look you. All of you. We danced†¦ Let either of you breathe a word†¦ I will come to you in the black of some terrible night and I will bring a pointy reckoning that will shudder you† (Miller 20). She does this to also avoid being arrested. Not only does Abigail lie about witchcraft, she also stuffs the needle in the doll that Mary Warren made for Elizabeth. Cheever explains, â€Å"The girl, the Williams girl, Abigail Williams, sir. She sat to dinner in Reverend Parris’s house tonight†¦ she falls to the floor†¦ he goes to save her, and, stuck two inches in the flesh of her belly, he draw a needle out. And demandin’ of her how she come to be stabbed† (Miller 74). Abigail uses this situation to accuse Elizabeth of practising witchcraft to harm her Abigail. She does this to sabotage Elizabeth and, eventually, take her place as John Proctor’s wife. Abigail’s callousness with Elizabeth shows that her selfishness has no bounds or morals. If greed and selfish are not bad enough human characteristics, betrayal is perhaps the most cunning and provides the most false sense of security. Mary Warren accuses John Proctor of consorting with the devil and pressuring her to join him in his evil ways, which is not true. As Mary yells in anger, she says pointing at Proctor, â€Å"You’re the Devil’s man!† (Miller 118). She continues on to say â€Å"I’ll not hang with you! I love God, I love God† (118). Mary Warren’s loyalty to John Proctor is betrayed under pressure to save her own life rather than be hanged. Abigail betrays Tituba so that she does not get question by Reverend Hale. What Abigail says to Hale and Parris when she falsely accuses Tituba is â€Å"She sends her spirit on me in church; she makes me laugh at prayer!† (Miller 44). Abigail does not want to confess her practise of witchcraft in the forest with her girls at night. While in the play there is no shortage of characters willing to do the wrong thing in life, choosing to do the right thing is always the preferred path in life. Having to replace any form of righteousness (justice) with greed, selfishness or betrayal does not justify our actions or means for the end result. Each one of the characters in the crucible mention in the above paragraph have all demonstrated that some form of human nature for self rewardance was place before justice/righteousness. There are always consequences when the truth is not told. Whenever we use these actions in our character they always lead us away in the opposite  direction from our true and honest goals. Righteousness in the heart produces beauty in the character. Works Cited Miller, Arthur. The Crucible. New York: Penguin Books, 1976. Print

Professional Knowledge and Abilities

Professional Knowledge and Abilities Free Online Research Papers Maintaining professional knowledge and abilities is essential to one’s career success. The continued striving for additional knowledge related to one’s professional field, or the attainment of knowledge from reliable and credible sources and organizations, allow an individual to possess the knowledge and abilities needed to succeed within a particular field. Various organizations and associations allow an individual from any professional field to further develop or enhance professional abilities and knowledge of a chosen profession. American Psychological Association Overview The American Psychological Association is the largest association of psychologists with over 150,000 members. This global organization functions with the mission to aid society as a whole by improving lives of those dealing with psychological illness. Working continually to advance knowledge of mental illness, awareness, and treatment methods the American Psychological Association is the optimal source for professional knowledge and abilities for any individual entering or currently working within the field of psychology (American Psychological Association, 2010). Increasing Professional Knowledge and Abilities The individual seeking to enter or currently working within the psychology field will find a plethora of opportunity for increasing his or her professional knowledge and abilities through membership with the American Psychological Association. The organization’s purpose is to advance psychology both as a science and profession, and to also act as the leading means to the promotion of health, education, and human welfare (American Psychological Association, 2010). The American Psychological Association offers its members in all branches of psychology encouragement and continually seeks to improve the understanding and methods of psychology through research. The association also implores its members to hold to very high standards of ethics, conduct, education and achievement. The member of the American Psychological Association is able to enhance or further develop his or her knowledge and abilities through various meetings, reports, discussions and publications and acts as a valuable resource for professional contacts (American Psychological Association, 2010). Impact on Career Success The individual seeking a career in psychology will undoubtedly find the American Psychological Association to have vast impact on his or her career success. By becoming a member of the association one is able to achieve increased success with the utmost respect from colleagues and clientele when one follows the Ethical Principles of Psychologists and Code of Conduct. These principles and code of conduct supply the professional with a guide to behavior which will enable the professional to function within the professional field and address many issues of ethical dilemmas the professional may face throughout his or her career (American Psychological Association, 2010). For the new professional just entering the field these guidelines are essential for success and advancement potential. The American Psychological Association also makes available to the professional countless resources for credible and current information regarding any matter related to psychology which will enable the professional to always have access to valuable information required for treating those who suffer from mental illness. In addition, the association acts as the source for scholars seeking a degree in psychology to learn the standards associated with scholarly writings one will be required to complete throughout one’s educational experience (American Psychological Association, 2010). Conclusion In any profession one must continue to attain higher levels of professional knowledge and abilities in effort to achieve professional success. Regardless of the chosen career path an individual follows failure to seek additional knowledge and enhanced professional abilities will limit the chances of success in modern society which is ever-changing. Through research one is able to assimilate oneself with various professional organizations and associations such as the American Psychological Association, which offer valuable resources to the professional which can increase success for the professional in his or her chosen field. References American Psychological Association. (2010). About the American Psychological Association. Retrieved Feburary 5, 2010, from apa.org/about/ American Psychological Association. (2010). Ethical principles of psychologists and code of conduct 2002. Retrieved Feburary 5, 2010, from apa.org/ethics/code2002.pdf Research Papers on Professional Knowledge and AbilitiesThree Concepts of PsychodynamicInfluences of Socio-Economic Status of Married MalesThe Relationship Between Delinquency and Drug UseAnalysis Of A Cosmetics AdvertisementThe Project Managment Office SystemThe Effects of Illegal ImmigrationStandardized TestingEffects of Television Violence on ChildrenOpen Architechture a white paperAnalysis of Ebay Expanding into Asia

Emotion and Thomas G. Plummer Essay Example

Emotion and Thomas G. Plummer Essay Example Emotion and Thomas G. Plummer Essay Emotion and Thomas G. Plummer Essay Cheyenne Pruett Ms. Mitchell College Composition October 8, 2013 Ophelia? Thomas G. Plummer, in his essay Diagnosing and Treating the Ophelia Syndrome argues that the system we use for teaching today takes away students ability to think for themselves. Plummer proves his argument with loads of examples of students conforming to others to take the easy way out. In Plummers essay he points out ways to treat this syndrome and stop all ignorant people from ruining the minds of other students. Plummers purpose is to point out the issue that society is molding into uneducated individuals. Plummer writes in a formal tone for his target audience. Plummer appeals to pathos when he adds the quote about people not knowing how to answer simple questions such as How are you? How do you feel? because we are too busy Feeling what we are supposed to feel. He also strikes an emotional cord when he introduces the Treatments. The treatments in and of themselves are appealing to pathos because they all stimulate some kind of emotional response. Treatment 2 is all about trusting yourself. Later on in the discussing the treatments Plummer talks about how every throught he has are his thoughts. He says to follow your intuition. Just be you. Treatment three also has a lot of pathos. It is all about being okay with not knowing. He puts it into deep words when he says surrender the need for absolute truth. Plummer also uses formal diction to get his point across and to also help achieve the objective to make his argument stronger. In using words such as pontificates and clamors, he is making it clear who his target audience is. Even Just adding the treatments can be considered formal diction. The treatments are his way of showing/ telling the audience that something can be done to reverse the effects of Ophelia Syndrome. Other formal words such as morality and counterargument can be found throughout the essay. The word choice in the essay helps provide us with a clear example of who should be reading the essay. In using formal diction he is establish his credibility. Plummer also establishes credibility/ appeals to ethos when he talks about psychologist Carl Jung on the first page of his essay. Adding other insight can help the audience show that the author, Plummer in this case, did his research and knows about the topic he is writing about. Another appeal to ethos Plummer makes is on sixth page under treatment 4, when he adds Psychologist Lawrence Kohlberg defines morality as the ability to see as issue from points of view ther than Just your own. Plummer later on goes on to explain a personal experience with treatment 6 which is step out of bounds, when he explains he dutifully carried prepared tests to his class. There was a student Holly who practiced Plumbers treatment when he walked through the door and she looked him because it is a personal experience. Plummer had a number of things he used to get his point across. He used all of his appeals and great diction as well as others to m ake sure his target audience was right on with him. He kept the essay flowing and easy.

Engineering Management Research Paper Example | Topics and Well Written Essays - 3000 words

Engineering Management - Research Paper Example An engineer is supposed to study the principles of engineering management if he wants to become a successful professional in the field of engineering because the increasing competition in the market due to the limitations put up by the scarcity of resources has made it mandatory for the engineers for have a basic knowledge of management and planning strategies which were deemed as unnecessary for the engineers in past. Engineers are supposed to develop a knowledge of financial management, marketing strategies, risk management in addition to project management techniques in order to excel in the field of engineering and this knowledge should be gained before going out in the field (Shainis, Dekom & McVinney, 1995). I got my first experience of working as an engineer when I worked as a chemical engineering intern in a fertilizer plant. My stay at the organization and the plant was very knowledgeable experience as I managed to spend some time in each of the various operational sections of the organization. My knowledge of the various engineering management sessions helped me a lot during the planning and execution of the various projects which were assigned to me during my work at various sections in the organization and I managed to complete all of the projects whether they were related to research, design or operation with great success and thus I realized the importance of the study of engineering principles in order to become a successful engineering professional.

Common Law - business Assignment Example | Topics and Well Written Essays - 1250 words

Common Law - business - Assignment Example Respondeat superior and quifacit per alium facit per se are the two principles that vicarious liability is based on. According to respondeat superior, a superior is responsible for the acts committed by his subordinates. Quifacit per alium facit per se means that if someone does something through another, then he does it through himself (Giliker, 2010). The rules that the court applies in deciding if the blame for a tortuous act can be shifted from the employee to the employer are: Control Test: Was the employee under the control of the employer when the tortuous act was committed? Control is the key characteristic that the court will consider. The employer must have the control and the ability to exert authority over the employee. That is the employer controls the actions of the employee’s work. He must instruct the employee on what to work on and how to work on. Control, authority and direction are necessary liability conditions (Giliker, 2010). Employment Test: An employer will only be liable to acts of employees and not independent contractor. That is, employees have a ‘contract of service’ while an independent contractor will have a â€Å"contract for service’. Course of employment: Employer is liable only if the tort was committed in the course of the employment. That is the blame can be shifted from the employee to the employer if the tortuous act was authorised by the employer or the authorised act was done in a wrongful way (Smith & Thomas, 2007). 3b. Occupier’s liability act of 1957: This act deals with the liability of the occupier to the lawful visitors. The act treats all visitors as a single entity irrespective of them being invitees, contractors and licensees. It is not applicable to illegal visitors such as trespassers. It imposes duty of care on the occupier. According to the act, an occupier is one who has reasonable control on the premises and must have had the ability to avoid or prevent the danger. Common Duty of Care: An occupier owes a common duty of care to all legal visitors wherein care must be taken by the occupier to ensure that the visitor is safe in using the premises for which he was invited under all reasonable circumstances (Harpwood, 2008). Warnings: Occupiers are not held liable if harm is caused to a visitor if he/she had been warned about the danger. The visitor under all circumstances must be able to avoid the danger based on warnings. But apart from warnings extra care must be taken if the danger is unusual or extreme (Harpwood, 2000). Children and professional exercising their duty: Exceptions are made to children and persons who are exercising a skill or trade. With children, the occupier must ensure that children are safe considering the fact they are less careful than adults. For Example, in Glasgow Corpn v Taylor (1922) a child died after eating poisonous berries from a bush in a public park. The bush was not fenced and hence did not take care in safeguarding c hildren. The occupiers were held responsible (Harpwood, 2000). With persons exercising their duties the occupier can expect the person to be aware of special risks associated with the skill. For example, an electrician repairing an electric socket must be aware of the danger of dealing with electrical equipment and must be careful in dealing with it. Independent Contractors: The occupier cannot be held liable if the danger or harm is caused by the work of an independent contractor